to not be able to put up with something, or not be able to suffer through it any longer (see Molina)
Alonso de Molina:
aocnoconyecoa. no poder ya con ello, o no poder ya sufrirlo. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 6v. col. 1. Thanks to Joe Campbell for providing the transcription.