to contend, fight, quarrel with someone (see Molina)
Orthographic Variants:
ixquaqua
Alonso de Molina:
ixquaqua. nite. (pret. oniteixquaqua.) contender, o rifar con otro. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 47r. col. 1. Thanks to Joe Campbell for providing the transcription.