something that has been greatly discussed or examined, or something that has been twisted and turned many times (see Molina)
IPAspelling:
tɬɑkweːkweːpɑlli
Alonso de Molina:
tlacuecuepalli. cosa bien discutida y examinada o cosa que sea buelto y rebuelto muchas vezes. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 119v. col. 2. Thanks to Joe Campbell for providing the transcription.