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-tzin-.

Headword: 
-tzin-.
Principal English Translation: 

reverential suffix for nouns, also sometimes diminutive, or implying pity or tenderness
James Lockhart, Nahuatl as Written: Lessons in Older Written Nahuatl, with Copious Examples and Texts (Stanford: Stanford University Press and UCLA Latin American Studies, 2001), 240.

Andrés de Olmos: 

Otras vezes es particula de reuerencia junatandola a los nombres.
Andrés de Olmos, Arte para aprender la lengua Mexicana, ed. Rémi Siméon, facsimile edition ed. Miguel León-Portilla (Guadalajara: Edmundo Aviña Levy, 1972), 187.

Lockhart’s Nahuatl as Written: 

pl. -tzitzīn(tin).
James Lockhart, Nahuatl as Written: Lessons in Older Written Nahuatl, with Copious Examples and Texts (Stanford: Stanford University Press and UCLA Latin American Studies, 2001), 240.

Attestations from sources in English: 

Frances Karttunen, in an unpublished study of the hieroglyphic place names in the Codex Mendoza, suggests a meaning of "new," "lower," or "little," to refer to the nature or location of the place.