to play a vihuela (guitar-like instrument), a harp, or the like (see Molina)
Orthographic Variants:
mecaueuetzotzona, mecauehuetzotzona
IPAspelling:
mekɑweːweːtsotsonɑ
Alonso de Molina:
mecaueuetzotzona. ni. (pret. onimecaueuetzotzon) tañer viguela harpa, o cosa semejante. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 55r. col. 1. Thanks to Joe Campbell for providing the transcription.