a ball game played with the hand, and the act of playing (see Molina)
Alonso de Molina:
nematepayolhuiliztli. juego de pelota conla mano. s. el acto de jugar. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 67r. col. 1. Thanks to Joe Campbell for providing the transcription.