to do wrong or hurt someone; o r, to speak in a way that the sentence is not well stated or only stated cautiously and warily (see Molina)
Alonso de Molina:
tlacocolhuia. nite. (pret. onitetlacocolhui.) hazer mal, o lastimarle algo a otro, o hablar de manera que no se declare bien la sentencia y cautelosamente. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 118r. col. 2. Thanks to Joe Campbell for providing the transcription.