(you all need to be) informed, prudent, and knowing (see Molina)
Orthographic Variants:
amix amonacaz xiccuicau
Alonso de Molina:
amix amonacaz xiccuicau. sed auisados prudentes y sabios. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 5r. col. 1. Thanks to Joe Campbell for providing the transcription.