an ache in the eyes from too much reading (see Molina)
Orthographic Variants:
ixquaquauhtiliztli
Alonso de Molina:
ixquaquauhtiliztli. dolor de ojos tal. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 47r. col. 1. Thanks to Joe Campbell for providing the transcription.