to smile or to make gestures while laughing (see Molina)
Orthographic Variants:
ixuetzca
Alonso de Molina:
ixuetzca. n. (pret. onixuetzcac) sonreirse, o hazer gestos con risa. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 48v. col. 2. Thanks to Joe Campbell for providing the transcription.