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iyuca yeliztli.

Headword: 
iyuca yeliztli.
Principal English Translation: 

loneliness of someone who is alone or has been left alone (see Molina)

Orthographic Variants: 
iuhcah yeliztli, iuhca yeliztli
Alonso de Molina: 

iyuca yeliztli. soledad del que esta solo y desacompañado.
Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 37r. col. 1. Thanks to Joe Campbell for providing the transcription.