to have an illness of the hands; or, to be one-handed (see Molina)
IPAspelling:
mɑːkwekwe
Alonso de Molina:
macuecue. enfermo o manco de las manos. 71m2-51r. col. 1. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. Thanks to Joe Campbell for providing the transcription.