a vexation, or a feeling of fatigue caused by something or someone (see Molina)
Alonso de Molina:
teciammictiliztli. vexacion, o fatiga desta manera. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 92v. col. 1. Thanks to Joe Campbell for providing the transcription.