an obstacle or an impediment to something (see Molina)
Orthographic Variants:
tlayelleltiliztli
IPAspelling:
tɬɑeːlleltilistɬi
Alonso de Molina:
tlaelleltiliztli. estoruo o impedimento de algo. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 120v. col. 1. Thanks to Joe Campbell for providing the transcription.