a large and abominable sore, open wound, or ulcer (see Molina)
Orthographic Variants:
tlayelpalaxtli
Alonso de Molina:
tlaelpalaxtli. llaga grande y abominable. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 120v. col. 1. Thanks to Joe Campbell for providing the transcription.