an itch, a tingling sensation, or a twinge (see Molina)
Alonso de Molina:
yoyomiquiliztli. comezon. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 39v. col. 1. Thanks to Joe Campbell for providing the transcription.