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iztlacyo.

Headword: 
iztlacyo.
Principal English Translation: 

something that is harmful to one's health, poisonous, can damage or put an end to morality, long ritual practices (see Molina)

Alonso de Molina: 

iztlacyo. cosa ponzoñosa.
Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 49v. col. 2. Thanks to Joe Campbell for providing the transcription.