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machacayolin.

Headword: 
machacayolin.
Principal English Translation: 

calluses, the type that appear on the hands (see Molina)

IPAspelling: 
mɑːtʃɑkɑjolin
Alonso de Molina: 

machacayolin. callos de las manos.
Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 50v. col. 1. Thanks to Joe Campbell for providing the transcription.