to have pain in the hands, like arthiitis (see Molina)
IPAspelling:
mɑːkokototstik
Alonso de Molina:
macocototztic. gotoso de las manos. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 51r. col. 1. Thanks to Joe Campbell for providing the transcription.