to be a cart driver; or, to drive carts (see Molina)
Orthographic Variants:
quauhtemalacayacana
Alonso de Molina:
quauhtemalacayacana. ni. (pret. oniquauhtemalacayacan.) ser carretero, o carretear. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 86v. col. 2. Thanks to Joe Campbell for providing the transcription.