to become annoyed, or tired; to be annoying, or to be of inconvenience to another (see Molina)
Alonso de Molina:
xixiuhtlatia. nino. (pret. oninoxixiuhtlati) enhadarse, o cansarse.
xixiuhtlatia. nite. (pret. onitexixiuhtlati.) enhadar, o ser importuno a otro. Alonso de Molina, Vocabulario en lengua castellana y mexicana y mexicana y castellana, 1571, part 2, Nahuatl to Spanish, f. 160r. col. 1. Thanks to Joe Campbell for providing the transcription.