for something to turn out to be in vain, to be frustrated (see Karttunen)
worthless person, good for nothing (see Karttunen)
to be afflicted, to feel anquish (reflexive), or to inflict these things on others (transitive) (see Molina)
to feel malaise, be unhappy, languish James Lockhart, Nahuatl as Written: Lessons in Older Written Nahuatl, with Copious Examples and Texts (Stanford: Stanford University Press and UCLA Latin American Studies, 2001), 227.
one who is anguished; a uselessly wise person (see Molina)
to be belittled by others (see Molina)
in vain.