some sort of severe affliction or calamity James Lockhart, Nahuatl as Written: Lessons in Older Written Nahuatl, with Copious Examples and Texts (Stanford: Stanford University Press and UCLA Latin American Studies, 2001), 215.
something that burns the mouth, such as hot peppers (see Molina); misery, tribulation, affliction (see attestations); also, a person's name, attested as male, Cococ
an herb (possibly Bocconia frutescens) used in a remedy for urinary obstruction
Fr. Bernardino de Sahagún, Florentine Codex: General History of the Things of New Spain; Book 10 -- The People, No. 14, Part 11, eds. and transl. Arthur J. O. Anderson and Charles E. Dibble (Santa Fe and Salt Lake City: School of American Research and the University of Utah, 1961), 159 and 161 note 5.